The U6 haplogroup has a southwestern asia origin approximately 40,000 or 45,000 years ago. The early Upper Paleolithic carrying U6 return to Africa from the Mediterraneen area. This expansion had affected, not only north Africa, but also Near East, Iberian Peninsula and Canary Island. Then U6 haplogroup diffused to Europe through Gibraltar straits or Sicily, but also in sub-saharan regions.